Quadriceps Satellite Cells Show Superior Regenerative Potential Compared to Diaphragm Cells
Evaluation of the Regeneration Capacity of Satellite Cells From the Quadriceps Compared to That of the Diaphragm
Background
Critically ill patients undergoing mechanical ventilation frequently suffer from severe muscle wasting and diaphragm injury, significantly hindering recovery and increasing mortality. Satellite cells, the resident stem cells of muscle, are vital for muscle repair and regeneration. However, their regenerative capacity can vary significantly between different muscle groups and may be compromised in disease states. This study aimed to compare the intrinsic regenerative potential of satellite cells isolated from the quadriceps versus the diaphragm in patients experiencing mechanical ventilation complications.