22 studies on P21 curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
Liraglutide significantly upregulated GLP1R expression and activated cAMP/PKA signaling, inducing apoptosis and cell cycle arrest in MCF7 breast and PC-3 prostate cancer cells.
This study identifies OVCA2 as a novel oncogene and a promising therapeutic target in pediatric AML by elucidating its mechanism of CDKN1A regulation. Understanding this pathway could lead to the development of new ta…
This discovery represents a significant advancement in our fundamental understanding of DNA replication fidelity and the maintenance of genome stability. By identifying the Atad5 RFC-like complex as the primary PCNA u…
Accurate and transparent reporting of methodology, especially in data visualization, is absolutely critical for scientific reproducibility and interpretation. This correction ensures that future researchers interpreti…
The investigation revealed that TRPV1 activation significantly attenuated several critical markers of aortic aging in the atherosclerotic mouse model when compared to untreated control groups. Specifically, treated mi…
This research identifies p21+TREM2+ senescent macrophages as a critical and previously unrecognized driver of MASLD and associated inflammaging. The findings provide a novel understanding of how cellular senescence co…
This study provides compelling evidence that Humanin-G possesses significant neuroprotective capabilities in a preclinical model of retinal degeneration. The observed preservation of both retinal structure and functio…
The discovery of Plumbagin as a potent GGCT inhibitor opens new avenues for developing targeted cancer therapies. By inhibiting GGCT, Plumbagin could disrupt glutathione metabolism in cancer cells, making them more su…
This research fundamentally shifts our understanding of IGF-1's role in aging, proposing a biphasic model that moves beyond simple 'more is better' or 'less is better' paradigms. The identification of an IGF-1 senesce…
This research provides compelling evidence that cellular senescence in adipocytes directly contributes to insulin resistance, offering a novel mechanistic link between aging and metabolic disease. The findings suggest…
This research highlights the therapeutic potential of senolytic peptides like FOXO4-DRI in targeting and removing harmful senescent cells from cartilage. By selectively eliminating these dysfunctional cells, FOXO4-DRI…
This research highlights FOXO4-DRI as a potent anti-senolytic agent, capable of rejuvenating endothelial cells and improving vascular health by modulating the P53 pathway. The ability to reverse cellular aging in the …
This research is critical for understanding the molecular mechanisms behind skin aging and its response to environmental stressors like UVB. If Insulin-Like Growth Factor 1 proves effective in modulating gene expressi…
This study is significant because it could establish Adrenomedullin as a crucial biomarker for Acute Myeloid Leukemia prognosis and treatment response. If Adrenomedullin levels accurately reflect disease burden and pr…
This study represents a crucial step towards developing more effective and potentially less toxic treatments for pediatric CNS malignancies. The SGT-53 gene therapy, which targets the p53 tumor suppressor gene (a crit…
This study is crucial for understanding the pleiotropic effects of metformin beyond its well-known glucose-lowering capabilities, specifically its potential role in modulating molecular aging processes in prediabetes.…
This research highlights TSPAN9 as a novel and potent regulator of chondrocyte health, offering a promising therapeutic avenue for osteoarthritis. By promoting mitocytosis, TSPAN9 effectively clears damaged mitochondr…
This research highlights the critical role of glial cell senescence as a potential driver of Alzheimer's Disease progression, rather than merely a consequence of aging. Understanding these cell type-specific and age-d…
This study represents a significant breakthrough, demonstrating that rational design can yield potent and selective allosteric activators of PAK1 with therapeutic potential. The robust improvements in cognition, synap…
This research elucidates a critical molecular pathway by which GHRH antagonists like JMR-132 exert their anti-cancer effects, specifically highlighting the essential role of p21/waf1 (a protein that halts cell divisio…
This research highlights the therapeutic potential of GHRH antagonists as a novel and targeted approach for treating prostate cancer. By modulating key cellular pathways, specifically restoring the function of the p53…
This research significantly advances our understanding of the molecular basis of umami taste, particularly through the novel mechanism of peptide mineral chelates. The identification of specific potent umami peptides …
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