100 studies (1 from unattributed sources) on Mots-c curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
Independent certificate-of-analysis evidence from third-party labs — the data behind the studies. Updated as new COAs are verified. Read the full grey-market analysis →
| Manufacturer | Batches | Avg purity | |
|---|---|---|---|
| Verified Peptides | 20 | 99.56% | View COA → |
| Uther Peptide | 11 | 99.4% | View COA → |
| Qingdao Sigma Chemical | 8 | 99.42% | View COA → |
| (unknown) | 7 | 99.53% | View COA → |
| Shanghai Sigma Audley Ssa | 7 | 99.52% | View COA → |
| Lilipeptide | 7 | 99.23% | View COA → |
| Reta Peptide | 6 | 99.57% | View COA → |
| Aminos Research | 5 | 99.76% | View COA → |
Recent certificates: #21905 (98.7%) · #14811 (99.174%) · #21906 (99.4%) · #14490 (99.7%) · #14578 (99.298%) · #13237 (99.139%)
Manufacturers with published third-party certificates of analysis for Mots-c. Open a vendor to see every batch we've verified.
This research identifies MOTS-c as a promising therapeutic strategy for improving outcomes in soft tissue transplantation and reconstructive surgery, particularly in scenarios prone to ischemic necrosis. By targeting …
This research highlights MOTS-c as a potential therapeutic agent for preventing or treating hyperoxia-induced neonatal cardiac injury, a condition with limited specific treatments. Understanding that MOTS-c acts by in…
This pilot study highlights the complex and potentially dual role of MOTS-c in peritoneal dialysis (PD) patients, suggesting it could be a valuable biomarker for cardiovascular disease (CVD) risk. Monitoring MOTS-c le…
This research highlights MOTS-c's potential as a novel and promising biomarker for assessing the severity of myocardial ischemia-reperfusion injury (IRI) in acute myocardial infarction (AMI) patients. Identifying pati…
These findings suggest that MOTS-c could serve as a novel biomarker for PCOS diagnosis or severity, and its genetic variants might identify individuals at higher risk. Understanding this metabolic link opens avenues f…
This research highlights MOTS-c as a promising therapeutic candidate for conditions involving impaired spermatogenesis. By targeting SLC7A11 and suppressing ferroptosis, MOTS-c offers a novel mechanism to protect germ…
This ongoing TONE Trial holds immense importance as it seeks to provide robust, high-quality evidence for the efficacy of structured, high-intensity combined exercise in a particularly vulnerable patient population: t…
Understanding the role of exercise in post-diagnosis breast cancer care is crucial for improving patient outcomes and quality of life. If this pilot study demonstrates positive changes in body composition and identifi…
The ability to accurately predict cardiovascular mortality in Type 2 Diabetes Mellitus patients with Coronary Artery Disease is paramount for enhancing patient care and improving long-term outcomes. Positive findings …
MOTS-c is a novel mitochondrial-derived peptide with potential roles in metabolic regulation, including glucose homeostasis. If this Phase 2a study demonstrates significant improvements in insulin sensitivity and a fa…
Understanding the evolutionary history and selective pressures on humanin and SHLP6 provides crucial insights into their functional significance and potential roles in health and disease. The identification of sites u…
This study provides compelling evidence that circulating MOTS-c levels are significantly associated with both metabolic health and the severity of liver fibrosis in patients with MAFLD. The consistent inverse relation…
This research uncovers a novel antiviral mechanism for MOTS-c, demonstrating its potent ability to combat HBV infection by modulating mitochondrial dynamics. This unique approach could offer a significant advantage ov…
These findings are significant because they identify MOTS-c as a potential biomarker for lower-body muscle strength, independent of aerobic fitness. This specificity could make MOTS-c a valuable tool for assessing mus…
The findings suggest that MOTS-c holds significant promise as a novel therapeutic agent for managing inflammatory pain, leveraging its ability to act on both central and peripheral pain pathways. This dual mechanism o…
This study highlights MOTS-c as a crucial mediator of the cardioprotective effects of aerobic exercise in diabetic myocardial injury, primarily through enhancing antioxidant defense. The findings suggest that targetin…
This research highlights the significant therapeutic potential of MOTS-c as a novel intervention for myocardial infarction, offering a promising strategy beyond conventional treatments. By targeting mitochondrial func…
This study provides compelling evidence that MOTS-c peptide could be a novel and effective therapeutic agent for diabetic cardiomyopathy. Its ability to improve cardiac function, reduce fibrosis, and mitigate oxidativ…
This research strongly positions mitochondrial-derived peptides as a novel and potent class of therapeutic agents for the management of Type 2 Diabetes. Their ability to simultaneously improve insulin sensitivity, red…
This research highlights MOTS-c as a promising therapeutic agent for combating muscle wasting and associated fat infiltration caused by immobilization. The ability of MOTS-c to simultaneously preserve muscle mass and …
This research highlights MOTS-c as a novel and potent regulator of NASH progression, acting through a direct interaction with Bcl-2 to mitigate hepatic steatosis, inflammation, and fibrosis. The findings underscore th…
This research is significant because it reveals that radiation therapy has a systemic impact on mitochondrial-derived peptides, which are crucial for cellular resilience and metabolism. The observed decrease in Humani…
This research identifies DNA-PKcs as a critical driver of myocardial microvascular injury during sepsis, highlighting it as a promising therapeutic target. The findings also underscore the protective role of MOTS-c, s…
This study provides crucial in vitro evidence for the direct regulatory role of MOTS-c on pancreatic islet cells, suggesting its potential as a therapeutic agent for metabolic disorders. By simultaneously improving in…
This study provides compelling and novel evidence that central MOTS-c administration can significantly modulate reproductive hormones, with distinct effects depending on the metabolic state of the individual. The abil…
This research provides compelling evidence that MOTS-c offers significant protection against formyl peptide-induced acute lung injury by inhibiting FPR2-mediated ferroptosis and preserving endothelial barrier function…
This study underscores the critical role of mitochondrial MOTS-c (a mitochondrial-derived peptide involved in metabolic regulation) as a key mediator of exercise's beneficial effects on diabetes. The findings suggest …
This research provides compelling evidence that mitochondria-derived peptides represent a novel and promising therapeutic strategy for treating painful diabetic neuropathy. By directly targeting mitochondrial dysfunct…
The study unequivocally revealed a significant and consistent association between markers of mitochondrial dysfunction and poorer cognitive performance across several critical domains in adults with OSA. Specifically,…
This study identifies MOTS-c as a promising novel therapeutic agent for cancer-induced bone pain, addressing a significant unmet medical need in oncology. Its unique mechanism through AMPK-mediated mitochondrial bioge…
This groundbreaking research highlights MOTS-c as a highly promising novel therapeutic agent for the prevention and treatment of radiation pneumonitis. Its ability to simultaneously modulate inflammation, reduce oxida…
This study provides a robust mechanistic framework for understanding how MOTS-c protects the brain after traumatic injury, highlighting its role in enhancing mitochondrial function and reducing inflammation and oxidat…
This research is significant as it identifies Humanin and MOTS-c as potential protective agents against chemotherapy-induced reproductive damage. Given the devastating impact of male infertility on cancer survivors, f…
This research highlights MOTS-c as a promising, novel biomarker that can significantly refine risk prediction for mortality and cardiovascular events in chronic hemodialysis patients. Identifying high-risk individuals…
This comprehensive systematic review and meta-analysis solidifies the critical role of Mitochondrial Derived Peptides (MDPs) in metabolic regulation and disease pathogenesis. The consistent and robust correlations obs…
This research significantly advances our understanding of the pleiotropic benefits of SGLT2 inhibitors in diabetic heart failure. By demonstrating their ability to enhance protective mitochondrial peptides and mitigat…
This research highlights Pyrroloquinoline Quinone (PQQ) as a promising therapeutic agent for mitigating radiation-induced lung injury (RILI), a debilitating side effect of cancer radiotherapy. By demonstrating PQQ's a…
Understanding the role of MOTS-c in facilitating plasma membrane repair opens new avenues for therapeutic strategies. Given that cellular membrane damage is a fundamental component of numerous diseases and injuries, m…
This research positions MOTS-c as a novel and highly promising therapeutic candidate for ovarian cancer, offering a new avenue for treatment. By specifically targeting the USP7-LARS1 pathway, MOTS-c introduces a disti…
This research highlights the critical role of genetic predispositions, specifically the MOTS-c K14Q polymorphism, in age-related health decline. Understanding this genetic link could pave the way for personalized medi…
This research highlights MOTS-c's potential as a novel therapeutic agent to enhance the efficacy of existing cancer treatments by overcoming drug resistance, particularly in challenging tumor microenvironments like hy…
These findings are crucial as they identify multiple novel biomarkers that could potentially aid in the early detection and risk stratification of preeclampsia. Understanding the altered expression of VPO1, humanin, M…
This research provides a novel mechanistic understanding of how endurance training improves skeletal muscle mitochondrial function, highlighting MOTS-c as a key player. The findings suggest that circulating MOTS-c lev…
This research highlights MOTS-c as a promising, non-invasive biomarker for the early detection of Diabetic Kidney Disease (DKD) in children with Type 1 Diabetes Mellitus. Identifying DKD earlier could enable more time…
The most significant finding was that MOTS-c administration achieved comparable or superior protective effects to remote ischemic preconditioning in mitigating lung ischemia-reperfusion injury, reducing tissue damage …
This research significantly advances our understanding of MOTS-c as a potent regulator of muscle development and metabolism, highlighting its potential to improve muscle health across different fiber types. The findin…
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