Review Explores Antimicrobial Peptides' Diverse Roles in Neurodegeneration
The multifaceted role of antimicrobial peptides in neurodegeneration: Insights from Drosophila and beyond.
Background
Neurodegenerative diseases like Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by progressive neuronal loss, cognitive decline, and motor dysfunction, often involving neuroinflammation and protein aggregation. Current treatments are largely symptomatic, highlighting an urgent need for novel therapeutic strategies. This review synthesizes existing literature to provide a comprehensive understanding of the multifaceted mechanisms by which antimicrobial peptides (AMPs) might influence neurodegenerative pathologies.